191_calcium_dependent_enzymes_with_binding_site: Find reviewed enzymes that both require Ca(2+) as a cofactor and have an annotated calcium-binding site - two distinct annotation types (a stated cofactor requirement vs. an explicit structural binding-site position) corroborating each other for the same ion. Both sides are matched by the actual ChEBI identity of calcium(2+) (CHEBI:29108), not by name text: up:cofactor points directly at the ChEBI IRI, while a binding site's up:ligand is an instance further typed via rdfs:subClassOf to the ChEBI class

192_multifunctional_enzymes: Find reviewed multifunctional (multi-catalytic) enzymes: proteins annotated with more than one distinct EC number via up:enzyme or up:catalyticActivity - real biology (e.g. bifunctional enzymes in a biosynthetic pathway, or moonlighting enzymes), not just an EC-number-format curiosity.

193_book_citation_bibliographic_record: Find the full bibliographic record of a book chapter cited as evidence for a protein annotation: title, authors, editors, publisher, place and pages — distinct from the PubMed-ID-focused journal citation example (#19)

194_citation_erratum_chain: Find publications that have a published erratum/correction, linking the original citation to its corrigendum

195_submission_citation_database: Find proteins backed by a direct-submission citation, and which database (e.g. EMBL/GenBank/DDBJ, PDB) that submission was made to

196_proteome_related_by_similarity_score: Find the most closely related proteomes and the similarity score behind that relation. The score is not attached directly to the up:relatedProteome triple but to its RDF reification (rdf:Statement with matching rdf:subject/rdf:predicate/rdf:object)

197_proteome_panproteome_taxon: Given a strain-level proteome, find the taxon of the pan-proteome (species/strain group) it belongs to. up:panproteomeTaxon points directly at the Taxon

198_sequence_integrity_metadata: For reviewed human proteins, get the mass and MD5 checksum recorded on the canonical sequence together with the sequence length recorded on the corresponding UniParc entry — the kind of 'does this sequence match what I have locally' check downstream tooling actually runs

199_cds_sequence_discrepancy_note: Find a protein's cross-referenced CDS/nucleotide entry that disagrees with the reviewed Swiss-Prot sequence, together with the curator's note on why (e.g. different initiation, sequence problems, frameshift) — real curation-quality content, distinct from modeling detail

200_protein_conflicting_external_sequence: Find a protein's conflicting sequence: an alternative translation from a nucleotide entry that another group submitted, which disagrees with UniProt's own reviewed sequence for the same protein

201_isoform_modified_sequence_basis: Find a protein's modified (spliced) isoform sequence, the canonical sequence it is based on, and the alternative-splicing event annotation describing the difference between them

202_uniparc_sequence_cluster_membership: Find which UniRef clusters a specific sequence (identified by its UniParc entry) is a member of, using up:memberOf on the sequence itself. Distinct from the existing UniRef common-taxon example (#162), which starts from the cluster and asks for its up:member sequences — this starts from the sequence and asks which clusters it belongs to

203_cross_reference_url_reconstruction: For proteins cross-referenced to the AbasyAtlas database, reconstruct a working link to the external record by substituting the cross-reference's own identifier into that database's up:urlTemplate — exactly the kind of thing external tooling needs and currently has to hardcode per-database

204_taxon_name_variants: Find taxa with recorded name variants beyond their primary scientific name: a taxonomic synonym (an earlier or alternative Latin name for the same taxon) and other recorded name forms such as author citations or authority strings

205_taxon_abbreviated_lineage_flag: For human (taxon 9606), list every ancestor taxon in its lineage and whether that taxon is shown in UniProt's abbreviated lineage view (up:partOfLineage), as opposed to the full, non-abbreviated set of ancestors. Pairs with #183: since UniProt's taxonomy is pre-flattened, a single-hop rdfs:subClassOf already reaches every ancestor at any depth

206_alternative_name_kinds: Find proteins with a name of a specific, distinct naming convention beyond the ordinary recommended/alternative name pair: an allergen name (with the allergen nomenclature this comes from), a CD antigen name (HCDM nomenclature, e.g. for cell-surface markers), or an INN (international nonproprietary name, the standard name for a pharmaceutical substance such as a therapeutic antibody)

207_catalytic_activity_physiological_reaction: Find the physiological reaction (the direction/reaction an enzyme actually performs in vivo) associated with a catalytic activity annotation, using up:catalyzedPhysiologicalReaction, distinct from the general reaction the enzyme is capable of catalyzing (up:catalyzedReaction)

208_absorption_maximum_and_certainty: Find a protein's reported absorption maximum wavelength (up:maximum, in nm) together with up:certain, a qualifier flagging whether that reported value is certain or approximate

209_xenologous_interaction: Find protein-protein interactions flagged as xenologous (up:xeno), i.e. between molecules from different species, such as a host protein interacting with a pathogen protein — as opposed to an interaction between proteins of the same organism

210_mass_spectrometry_measured_value: Find a protein's mass spectrometry annotation with its measured mass (up:measuredValue) and, where recorded, the measurement's error margin (up:measuredError)

211_structure_resolution: Find the highest-resolution (lowest Angstrom value) experimentally determined structures cross-referenced from reviewed proteins, using up:resolution recorded on the PDB structure resource

212_enzyme_classification_replaced: Find EC (enzyme classification) numbers that have been replaced by a new EC number following reclassification, together with the new number's name. The old number itself no longer carries a name once replaced

213_protein_isolated_from_tissue: Find the tissue a protein was originally found to be expressed in from (up:isolatedFrom), distinct from its usual organism/subcellular-location annotations — the object is either a shared Tissue resource or a locally-defined (entry specific) tissue label

214_proteins_starting_with_methionine: Of reviewed human proteins, how many have a stored sequence starting with methionine (the universal translation start codon), and of those, how many have that initiator methionine later cleaved off post-translationally (up:Initiator_Methionine_Annotation with comment 'Removed') rather than retained in the mature protein

215_human_proteins_with_solved_structure: Count how many reviewed human proteins have at least one experimentally determined 3D structure cross-referenced from a PDB entry

216_human_proteins_by_existence_evidence: Break down reviewed human proteins by their protein-existence evidence level (up:existence): how many are 'very well characterized' with direct evidence at the protein level, as opposed to only evidence at the transcript level, inferred from homology, predicted, or uncertain