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http://purl.uniprot.org/citations/10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10950869http://www.w3.org/2000/01/rdf-schema#comment"TNFR1/Fas engagement results in the cleavage of cytosolic BID to truncated tBID, which translocates to mitochondria. Immunodepletion and gene disruption indicate BID is required for cytochrome c release. Surprisingly, the three-dimensional structure of this BH3 domain-only molecule revealed two hydrophobic alpha-helices suggesting tBID itself might be a pore-forming protein. Instead, we demonstrate that tBID functions as a membrane-targeted death ligand in which an intact BH3 domain is required for cytochrome c release, but not for targeting. Bak-deficient mitochondria and blocking antibodies reveal tBID binds to its mitochondrial partner BAK to release cytochrome c, a process independent of permeability transition. Activated tBID results in an allosteric activation of BAK, inducing its intramembranous oligomerization into a proposed pore for cytochrome c efflux, integrating the pathway from death receptors to cell demise."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/name"Genes Dev"xsd:string
http://purl.uniprot.org/citations/10950869http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10950869
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Gross A."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Wei M.C."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Lindsten T."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Thompson C.B."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Mootha V.K."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Weiler S."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Korsmeyer S.J."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/author"Ashiya M."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/pages"2060-2071"xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/title"tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c."xsd:string
http://purl.uniprot.org/citations/10950869http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/10950869http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10950869
http://purl.uniprot.org/uniprot/#_D3Z463-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
http://purl.uniprot.org/uniprot/#_A0A494BB74-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
http://purl.uniprot.org/uniprot/#_A0A494BBE8-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
http://purl.uniprot.org/uniprot/#_F7CUQ1-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
http://purl.uniprot.org/uniprot/#_O08734-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
http://purl.uniprot.org/uniprot/#_P55957-mappedCitation-10950869http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10950869
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