| http://purl.uniprot.org/citations/11832245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11832245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11832245 | http://www.w3.org/2000/01/rdf-schema#comment | "Polarization of the one-cell C. elegans embryo establishes the animal's anterior-posterior (a-p) axis. We have identified reduction-of-function anaphase-promoting complex (APC) mutations that eliminate a-p polarity. We also demonstrate that the APC activator cdc20 is required for polarity. The APC excludes PAR-3 from the posterior cortex, allowing PAR-2 to accumulate there. The APC is also required for tight cortical association and posterior movement of the paternal pronucleus and its associated centrosome. Depletion of the protease separin, a downstream target of the APC, causes similar pronuclear and a-p polarity defects. We propose that the APC/separin pathway promotes close association of the centrosome with the cortex, which in turn excludes PAR-3 from the posterior pole early in a-p axis formation."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Rappleye C.A."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Rappleye C.A."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Aroian R.V."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Aroian R.V."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Tagawa A."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Tagawa A."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Bowerman B."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Bowerman B."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Lyczak R."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/author | "Lyczak R."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/pages | "195-206"xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/pages | "195-206"xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/title | "The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/title | "The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation."xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00114-4"xsd:string |
| http://purl.uniprot.org/citations/11832245 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00114-4"xsd:string |