http://purl.uniprot.org/citations/12356731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12356731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12356731 | http://www.w3.org/2000/01/rdf-schema#comment | "IEX-1 is an early response and NF-kappaB target gene implicated in the regulation of cellular viability. We show here that IEX-1 is a substrate for ERKs and that IEX-1 and ERK regulate each other's activities. IEX-1 was isolated by phosphorylation screening with active ERK2 and found subsequently phosphorylated in vivo upon ERK activation. IEX-1 interacts with phosphorylated ERKs but not with c-jun N-terminal kinase (JNK) or p38. Upon phosphorylation by ERKs, IEX-1 acquires the ability to inhibit cell death induced by various stimuli. In turn, IEX-1 potentiates ERK activation in response to various growth factors. By using various IEX-1 mutants in which the ERK phosphoacceptor and/or ERK docking sites were mutated, we show that the IEX-1 pro-survival effect is dependent on its phosphorylation state but not on its ability to potentiate ERK activation. Conversely, IEX-1-induced modulation of ERK activation requires ERK-IEX-1 association but is independent of IEX-1 phosphorylation. Thus, IEX-1 is a new type of ERK substrate that has a dual role in ERK signaling by acting both as an ERK downstream effector mediating survival and as a regulator of ERK activation."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf488"xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf488"xsd:string |
http://purl.uniprot.org/citations/12356731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12356731 |
http://purl.uniprot.org/citations/12356731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12356731 |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Garcia J."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Garcia J."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Arranz V."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Arranz V."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Letourneux C."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Letourneux C."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Porteu F."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Porteu F."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Pezeron G."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/author | "Pezeron G."xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/pages | "5151-5163"xsd:string |
http://purl.uniprot.org/citations/12356731 | http://purl.uniprot.org/core/pages | "5151-5163"xsd:string |