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http://purl.uniprot.org/citations/14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14988498http://www.w3.org/2000/01/rdf-schema#comment"The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in immunity, we generated APRIL-deficient mice. APRIL(-/-) mice have normal T and B lymphocyte development, normal T and B cell proliferation in vitro, but increased numbers of CD44(hi)CD62L(lo) CD4(+) effector/memory T cells and increased IgG responses to T-dependent antigens. Serum IgA levels were significantly decreased, and serum IgA antibody responses to mucosal immunization with TD antigens and to type 1 T-independent antigens were impaired in APRIL(-/-) mice. APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/14988498http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0307348101"xsd:string
http://purl.uniprot.org/citations/14988498http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14988498
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Scott S."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Bhan A.K."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Geha R.S."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Mizoguchi E."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Dedeoglu F."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Castigli E."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Jabara H."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/author"Bryce P."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/pages"3903-3908"xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/title"Impaired IgA class switching in APRIL-deficient mice."xsd:string
http://purl.uniprot.org/citations/14988498http://purl.uniprot.org/core/volume"101"xsd:string
http://purl.uniprot.org/citations/14988498http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14988498
http://purl.uniprot.org/uniprot/#_A0A0A6YWR2-mappedCitation-14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14988498
http://purl.uniprot.org/uniprot/#_A0A0U5J5N9-mappedCitation-14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14988498
http://purl.uniprot.org/uniprot/#_A0A0A6YXW6-mappedCitation-14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14988498
http://purl.uniprot.org/uniprot/#_A0A075B5P3-mappedCitation-14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14988498
http://purl.uniprot.org/uniprot/#_A0A075B5P4-mappedCitation-14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14988498
http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14988498
http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-14988498http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14988498
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