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http://purl.uniprot.org/citations/17470632 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFRalpha and PDGFRbeta and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A-induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease."xsd:string |
http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
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http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/author | "Ball S.G."xsd:string |
http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/author | "Kielty C.M."xsd:string |
http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/author | "Shuttleworth C.A."xsd:string |
http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/pages | "489-500"xsd:string |
http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/title | "Vascular endothelial growth factor can signal through platelet-derived growth factor receptors."xsd:string |
http://purl.uniprot.org/citations/17470632 | http://purl.uniprot.org/core/volume | "177"xsd:string |
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